Which Drugs Affect Blood Glucose Levels? - 443 OTC & Prescription Meds (2023)

What drugs affect glucose levels? Many can, including steroids, anxiety and depression medications, statins, beta-blockers, some acne & asthma medications.

Knowing which drugs affect blood glucose levels is essential in properly caring for your diabetes patients. Some medicines raise blood sugar in patients while others might lower their levels. However, not all drugs affect patients the same way.

443 Drugs that can Affect Blood Glucose Levels is also available as a downloadable PDF.

Last Revised: 04/5/2020

Table of Contents:

Drugs that May Cause Hyperglycemia

Drugs that May Cause Hypoglycemia

Drugs that May Cause Hyper- or Hypoglycemia

Drugs that Mask Hypoglycemia

DiabetesinControl 2020©

Drugs That May Cause Hyperglycemia (High Blood Sugar)

Abacavir (Ziagen®)

Abacavir + lamivudine, zidovudine (Trizivir®)

Abacavir + dolutegravir + lamivudine (Triumeq®)

Abiraterone (Zytiga®)

Acetazolamide (Diamox®)

Acitretin (Soriatane®)

Albuterol (Ventolin®, Proventil®)

Albuterol + ipratropium (Combivent®)

Alectinib (Alecensa®)

Aliskiren + amlodipine + hydrochlorothiazide (Amturnide®)

Aliskiren + amlodipine (Tekamlo®)Ammonium chloride

Amphotericin B (Amphocin®, Fungizone®)

Amphotericin B lipid formulations IV (Abelcet®)

Amprenavir (Agenerase®)

Anidulafungin (Eraxis®)

Aripiprazole (Abilify®)

Arsenic trioxide (Trisenox®)

Asenapine (Saphris)

Asparaginase (Elspar®, Erwinaze®)

Atazanavir (Reyataz ®)

Atazanavir + cobistat (Evotaz®)

Atenolol + chlorthalidone (Tenoretic®)

Atorvastatin (Lipitor®)

Atovaquone (Mepron®)

Baclofen (Lioresal®)

Belatacept (Nulojix®)Benazepril + hydrochlorothiazide (Lotension®)

Betamethasone topical (Alphatrex®, Betatrex®, Beta-Val®, Diprolene®, Diprolene® AF, Diprolene® Lotion, Luxiq®, Maxivate®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Betamethasone +clotrimazole (Lotrisone® topical)

Betaxolol Betoptic® eyedrops, (Kerlone® oral)

Bexarotene (Targretin®)

Bicalutamide (Casodex®)

Bisoprolol + hydrochlorothiazide (Ziac®)

Brentuximab vedotin (Adcetris®)

Budesonide (Uceris®)

Bumetanide (Bumex®)

Caffeine (Caffeine in moderation may be beneficial in diabetes, but in large amounts can raise blood sugar.)

Calcipotriene + betamethasone (Enstillar®)

Candesartan + hydrochlorothiazide (Atacand HCT®)Captopril + hydrochlorothiazide (Capozide®)

Carfilzomib (Kyprolis®)

Cariprazine (Vraylar)

Carteolol (Cartrol® oral, Occupress® eyedrops)

Carvedilol (Coreg®)

Caspofungin (Cancidas)

Ceftaroline (Teflaro®)

Ceftozolane + tazobactam (Zerbaxa)

Ceritinib (Zykadia)

Chlorothiazide (Diuril®)

Chlorthalidone (Chlorthalidone Tablets®, Clorpres®, Tenoretic®, Thalitone®)

Choline salicylate (Numerous tradenames of aspirin formulations; check the label)

Choline salicylate + magnesium salicylate (CMT®, Tricosal®, Trilisate®)

Ciprofloxacin (Cipro)

Clobetasol (Clobevate®, Cormax®, Cormax® Scalp Application, Embeline® E, Olux®, Temovate®, Temovate® E, Temovate® Scalp Application)

Clozapine (Clozaril®, FazaClo®)

Conjugated estrogens (Estrace®, Estring®, Femring®, Premarin®, Vagifem®, Cenestin®, Enjuvia®, Estrace®, Femtrace®, Gynodiol®, Menest®, Ogen®)

Conjugated estrogens + bazedoxifene (Duavee®)

Conjugated estrogens + medroxyprogesterone (Premphase®, Prempro®)

Corticosteroids (Numerous tradenames; check the label)

Corticotropin

Cortisone (Numerous tradenames; check the label)

Crizotinib (Xalkori)

Cyclosporine (Sandimmune®, Neoral®, Gengraf®)

Dabrafenib (Tafiniar®)

Daclizumab (Zenapax®)

Darunavir (Prezista)

Darunavir + cobistat (Prezcobix®)

Decitabine (Dacogen®)

Desonide (DesOwen®, Tridesilon®)

Desoximetasone (Topicort®)

Dexamethasone (Adrenocot®, Dalalone®, Decadron®, Decaject®, Dekasol®, Dexacort®, Dexasone®, Dexim®, Dexone®, Hexadrol®, Medidex®, Primethasone®, Solurex®, Dexamethasone Intensol®)

Dextromethorphan + promethazine (Phenergan® with Dextromethorphan, Phen- TussDM®)

Diazoxide (Proglycem®)

Dinutuximab (Unituxin®)

Dolutegravir (Tivicay®)

Enalapril + hydrochlorothiazide (Vaseretic®)Encainide (Enkaid®)

Ephedrine and Guaifenesin (Primatene ® tablets, otc – this medication includes ephedrine and guaifenesin. Guaifenesin is not responsible for hyperglycemia )

Epinephrine (EpiPen ®, EpiPen® Jr, Primatene® Mist, otc)

Esterified estrogens, estrone, estropipate

Esterified estrogens + methyltestosterone (Estratest®)

Estradiol, ethinyl estradiol (Alora®, Climara®, Congest®, Delestrogen®, Depo-Estradiol®, Depogen®, Estinyl®, Estrace®, Estraderm®, Estragyn 5®, Estragyn LA 5®, Estrasorb®, EstroGel®, Estro-L.A.®, Gynodiol®, Kestrone-

5®, Neo-Estrone®, Menest®, Menostar®, Ogen .625®, Ogen®, Ortho-Est®, Premarin®, Valergen®, Vivelle®, Vivelle-Dot®)

Estradiol + norethindrone (Activella®)

(Video) Pharmacology - DRUGS FOR DIABETES (MADE EASY)

Estradiol + norgestimate (Prefest®)

Estramustine (Emcyt®)

Ethacrynic acid (Edecrin®, Sodium Edecrin®)

Etravirine (Intelence)

Everolimus (Afinitor®, Zortress®)

Everolimus (Zortress®)

Ezetimibe, Atorvastatin (Liptruzet®)

Fidaxomicin (Dificid®)

Fluconazole (Diflucan)

Fluticasone (Arnuity Ellipta®)

Fluticasone + vilanterol (Breo Elipta®)

Fluoxetine (Prozac®, Sarafem®)

Flurandrenolide (Cordran®, Cordran® SP, Cordran® Tape)

Fluvastatin (Lescol, Lescol XR)

Formoterol (Foradil® Aerolizer® Inhaler)

Fosamprenavir (Lexiva ®)

Fosinopril + hydrochlorothiazide (Monopril HCT®)

Furosemide (Lasix®)

Gabapentin (Gralise®, Horizant®)

Gemtuzumab ozogamicin (Mylotarg®)

Glucosamine (Possible increase in insulin resistance; more likely with intravenous use)

Glycopyrrolate (Cuvposa®)

Hydrochlorothiazide (Aldactazide®, Aldoril®, Capozide®, Dyazide®, HydroDIURIL®, Inderide®, Lopressor® HCT, Maxzide®, Microzide®, Moduretic®, Timolide®, Vaseretic®)

Hydrochlorothiazide + irbesartan (Avalide®)

Hydrochlorothiazide + lisinopril (Prinzide®, Zestoretic®)

Hydrochlorothiazide + losartan (Hyzaar®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Hydrochlorothiazide + moexipril (Uniretic®)

Hydrochlorothiazide + quinapril (Accuretic®, Quinaretic®)

Hydrochlorothiazide + telmisartan (Micardis HCT®)

Hydrochlorothiazide + valsartan (Diovan HCT®)

Hydrocortisone (Numerous trade names of topical hydrocortisone formulations; check the label)

Iloperidone (Fanapt)

Indacaterol (Arcapta®)

Indapamide (Lozol®)

Indinavir (Crixivan®)

Interferon alfa-2a (Roferon-A®)

Interferon alfa-2b (Intron-A®)

Interferon alfa-2b + ribavirin (Rebetron®)

Interferon alfa-n1 (Alferon-N®)

Irinotecan (Camptosar®)

Isavuconazonium sulfate (Cresemba)

Isoniazid (Laniazid®, Nydrazid®)

Isotretinoin (Accutane®)

Itraconazole (Sporanox, Sporanox PuslePak, Tolsura)

Ketoconazole (Nizoral)

Liothyronine (Cytomel®)

Lamivudine (Epivir®, Epivir-HBV®)

Levalbuterol (Xoponex®, Xopenex HFA®)

Levonorgestrel (Plan B®, Norplant System®)

Levothyroxine (Synthroid®, Levoxyl®)

Lisinopril + Hydrochlorothiazide

Lopinavir + ritonavir (Kaletra®)

Lovastatin (Altoprev, Mevacor)

Lucinactant (Surfaxin®)

Lurasidone (Latuda®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Medroxyprogesterone (Provera®, Depo-Provera®)

Megestrol (Megace®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Methylprednisolone (A-methaPred®, ADD-Vantage®, Depo-Medrol®, Medrol®,
Medrol® Dosepak, Meprolone® Unipak, Solu-Medrol®)

Metolazone (Zaroxolyn®, Mykrox®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Micafungin (Mycamine)

Modafinil (Provigil®)

Momentasone furoate + formoterol fumarate dihydrate (Dulera®)

Moxifloxacin (Avelox®, Avelox® I.V.)

Mycophenolate (CellCept®)

Nadolol (Corgard®)

Nelfinavir (Viracept®)

Netupitant + palonosetron (Akynzo®)

Niacin, niacinamide (Niacor®, Niaspan®, Nicolar®, Nicotinex®, Slo-Niacin®)

Nilotinib (Tasigna®)

Nilutamide (Nilandron®)

Nitric oxide (INOmax®)

Nivolumab (Opdivo®)

Norethindrone (Aygestin®, Nor-QD®, Micronor®)

Norgestrel (Orvette®)

Nystatin (Mycostatin®, Nystat-Rx®, Nystop®, Pedi-Dri®)

Nystatin + triamcinolone (Dermacomb®, Myco II®, Mycobiotic II®, Mycogen II®,
Mycolog II®, Myco-Triacet II®, Mykacet®, Mykacet II®, Mytrex®, Tristatin II®)

Octreotide (Sandostatin®, Sandostatin LAR®)

Olanzapine (Zyprexa®)

Olaparib (Lynparza®)

Olmesartan + amlodipine + hydrochlorothiazide (Tribenzor®)

Oxybutynin (Anturol®)

Oxycodone (Oxecta®)

Paliperidone (Invega, Invega Sustenna, Invega Trinza)

Panobinostat (Farydak®)

Pantoprazole (Protonix®, Protonix® I.V.)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Pegaspargase (Oncaspar®)

Peginterferon alfa-2b (PEG-Intron®, Sylatron®)

(Video) Statin Side Effects | Atorvastatin, Rosuvastatin, Simvastatin Side Effects & Why They Occur

Pembrolizumab (Keytrenda®)

Pentamidine (Pentam 300®)

Peramivir (Rapivab®)

Perindopril + amlodipine (Prestalia®)

Phenylephrine* (Sudafed PE®, and others)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Pitavastatin (Livalo, Zypitamag)

Pomalidomide (Pomalyst®)

Posaconazole (Noxafil)

Pravastatin (Pravachol)

Prednisolone (AK-Pred®, Blephamide®, Blephamide®, Liquifilm®, Econopred® Plus, Inflamase® Forte, Inflamase® Mild, Poly-Pred® Liquifilm®, Pred Forte®, Pred Mild®, Pred-G®, Pred-G® Liquifilm®, Delta Cortef®, Pediapred®, Prelone®)

Prednisone (Prednisone Intensol®, Sterapred®, Sterapred® DS, Rayos DR®)

Progesterone (Prometrium®)

Pseudoephedrine* (Claritin D®, Sudafed®, and others)

Quetiapine (Seroquel®)

Risperidone (Risperdal®, Risperdal® M-TAB®)

* many other OTC and prescription medications contain pseudoephedrine and phenylephrine.

Ritodrine (Yutopar®)

Ritonavir (Norvir®)

Rituximab (Rituxan®)

Rosuvastatin (Crestor)

Salmeterol (Serevent®, Serevent® Diskus®)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Saquinavir (Invirase®)

Simvastatin (Zocor)

Simvastatin + ezetimibe (Vytorin)

Sodium oxybate (Xyrem®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin artridges®, Norditropin NordiFlex®, Nutropin®, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)

Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued

Sonidegib (Odomzo®)

Sotalol (Betapace®, Betapace AF®, Sorine®)

Stavudine (Zerit)

Streptozocin (Zanosar®)

Tacrolimus (Prograf®, Protopic®)

Temsirolimus (Torisel®)

Tesamorelin (Egrifta®)

Thyroid (Armour Thyroid®, Naturethroid®)

Tiotropium + Olodaterol (Stiolto Respimat®)

Tipranavir (Aptivus®)

Tolvaptan (Samsca®)

Torsemide (Demadex®, Demadex Oral®)

Trametinib (Mekinist®)

Triamcinolone (Aristocort®, Aristospan®, Asthmacort®, Flutex®, Kenalog®, Tac®, Triacet®)

Umeclidium + vilanterol (Anoro Ellipta®)

Ursodeoxycholic acid, ursodiol (Actigall®, Urso®)

Valproic acid, divalproex sodium (Depacon®, Depakene®, Depakene® Syrup, Depakote®, Depakote® ER, Depakote® Sprinkle)

Vitamin C (Ascorbic acid, Ascorbate)

Vitamin E (Tocopherol, Tocotrienol)

Voriconazole (Vfend)

Zidovudine (Retrovir)

Ziprasidone (Geodone®)

Zolpidem (Intermezzo®)

Drugs That May Cause Hypoglycemia (Low Blood Sugar)

Acebutolol (Sectral®)

Acetohexamide (Dymelor®)

Albiglutide (Tanzeum®)

Alcohol

Albiglutide (Tanzeum)

Aloe – Oral Herbal Supplement, especially if taken with other agents such as glyburide, glipizide, nateglinide, repaglinide, glimepiride, or insulin.

Alogliptin (Nesina®)

Alogliptin/pioglitazone (Oseni®)

Alogliptin/metformin (Kazano®)

Amphotericin B (Ambisome®, Amphocin®, Fungizone Intravenous® Amphotec®, Abelcet®)

Amphotericin B lipid formulations (Abelcet®, AmBisome®)

Aripiprazole (Aristada®)Asian Ginseng (Ginseng; Panax ginseng)

Aspirin (Numerous tradenames; check the label)

Aspirin + dipyridamole (Aggrenox®)

Atenolol (Tenormin®, Tenoretic® containing atenolol & chlorthalidone)

Benazepril (Lotensin)

Betaxolol (Betoptic®, Betoptic S® eyedrops, Kerlone® oral)

Bisoprolol (Zebeta®)

Bisoprolol + hydrochlorothiazide (Ziac®)

Brexpiprazole (Rexulti®)

Bromocriptine (Cycloset®)

Canagliflozin (Invokana®)

Canagliflozin + metformin (Invokamet®)

Chloramphenicol (Chloromycetin®)

Chlorpropamide (Diabinese®)

Choline salicylate (Acuprin 81®, Amigesic®, Anacin Caplets®, Anacin Maximum Strength®, Anacin Tablets®, Anaflex 750® Arthritis Pain, Ascriptin® Arthritis Pain)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Choline salicylate + magnesium salicylate C (MT®, Tricosal®, Trilisate®)

Chloramphenicol (Chloromycetin, Econochlor, Ocu-Chlor)Chloroquine (Aralen)

Chromium (Various tradenames; check the label)

Ciprofloxacin (Cipro)

Clarithromycin B (Biaxin® Filmtab®, Biaxin® Granules, Biaxin® XL, Filmtab,
Biaxin® XL Pac, Prevpac®)

Clofibrate (Atromid-S)

Colesevelam (Welchol)

Dalbavancin (Dalvance®)

Dapagliflozin (Farxiga®)

Dapagliflozin + Metformin (Xigduo XR®)

Diazoxide (Proglycem®)

Dicumarol (Coumadin®, Miradon®)

Diltiazem (Cardizem®, Tiazac®)

(Video) The Foods That Help Lower Blood Sugar Levels

Disopyramide (Norpace®, Norpace® CR)

Dorzolamide + timolol (Cosopt®)

Doxepin (Silenor®)

Dulaglutide (Trulicity®)

Empagliflozin (Jardiance®)

Empagliflozin/linagliptin (Glyxambi®)

Empagliflozin + metformin (Synjardy®)

Enalapril (Vasotec)

Ertugliflozin ( Steglatro)

Ertugliflozin + metformin (Segluromet)

Ertugliflozin + metformin + linagliptin (Trijardy)

Esmolol (Brevibloc)

Exenatide (Byetta®, Bydureon®)

Fluoxetine (Prozac®, Sarafem®)

Fosphenytoin (Cerebyx®, Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Mesantoin®, Peganone®, Phenytek®)

Gatifloxacin (Gatiflo, Tequin, Zymar)

Glimepiride (Amaryl®)

Glimepiride and Rosiglitazone (Avandaryl®)

Glimepiride + pioglitazone (Duetact)

Glipizide (Glucotrol®, Glucotrol XL®)

Glipizide and Metformin (Metaglip®)

Glucagon (GlucaGen®)

Glyburide (Diabeta®, Glynase®, Micronase®, Glycron®)

Glyburide + metformin (Glucovance®)

Horse chestnut (Aesculus hippocastanum)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Hydroxychloroquine (Plaquenil)

Indomethacin (Indocin)

Insulin (Lantus®, Levemir®, NPH®, Humulin®, Novolin®, Apidra®, Novolog®, Humalog®, Tresiba®, Afrezza®- inhaled, Abasaglar®, Ryzodeg®, Xultophy®- not FDA approved, Toujeo®, Locemia®- not FDA approved, V-go®)

Interferon beta-1b (Betaseron®)

Isavuconazonium (Cresemba®)

ITCA 650®- Not FDA approved

Lenvatinib (Lenvima®)

Levobunolol (AKBeta, Betagan, Vistagan)

Levofloxacin (Levaquin®, Levaquin® in Dextrose Injection Premix, Quixin®)

Linagliptin (Tradjenta®)

Linagliptin + empagliflozin (Glyxambi)

Linagliptin + metformin (Jentadueto®, Jentadueto XR)

Liraglutide (Victoza®, Saxenda®)

Liraglutide + insulin degludec (Xultophy)

Lisinopril (Prinivil, Zestril, Qbrelis)

Lithium (Eskalith, Lithobid)

Lixisenatide (Lyxumia®)- currently approved in Europe

Lixisenatide/ insulin Glargine (Soliqua®)-

Lorcaserin (Belviq®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, Riomet®)

Metipranolol (Optipranolol)

metreleptin (Myalept®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Metreleptin (Myalept®)

Mifepristone (Korlym®)

Morphine (Kadian®, MS Contin®, MSIR®, Roxanol®)

Moxifloxacin (Avelox)

Nadolol (Corgard®)

Nateglinide (Starlix®)

Nebivolol (Bystolic)

Nifedipine (Adalat CC®, Procardia®, Afeditab ® CR)

Nivolumab (Opdivo®)

Norfloxacin (Noroxin)

Octreotide (Sandostatin®, Sandostatin LAR® Depot)

Ofloxacin (Oxuflox)

Oritavancin (Orbactiv®)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Paliperidone (Invega®)

Penicillamine (Cuprimine®, Depen®)

Pentamidine (Nebupent®, Pentam 300®)

Phenelzine (Nardil®)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Pindolol (Visken®)

Pioglitazone (Actos®) –( hypoglycemia usually only when in combination with other diabetic drugs such as sulfonylureas or insulin)

Pioglitazone and Glimepiride (Duetact®) – the glimepiride component of this drug gives it the possibility of causing hypoglycemia alone or in combination with other diabetes medicines. This is more likely to occur when one skips a regular meal or when unusual physical activities occur.

Pioglitazone and Metformin (Actoplus Met®, ActoPlus Met XR®)

Pramlintide (Symlin®)

Pregabalin (Lyrica®)

Probenecid (Benemid®, Probalan®)

Propranolol (Inderal) Quinine (Quinamm®, Quindan®, Quiphile®, Q-vel®, Strema®)

Quinupristin + dalfopristin (Synercid®)

Repaglinide (Prandin®)

Repaglinide and Metformin (PrandiMet®)

Ritodrine (Yutopar®)

Rituximab (Rituxan®)

Rosiglitazone (Avandia®)

Rosiglitazone and Metformin (Avandamet®)

Rotigotine (Neupro®)

Salicylates (Numerous tradenames of aspirin formulations; check the label)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Saxagliptin (Onglyza®)

Saxagliptin + dapagliflozin (Qtern)

Drugs That May Cause Hypoglycemia (Low Blood Sugar) – Continued

Saxagliptin + metformin (Kombiglyze XR®)

Saxagliptin + metformin + dapagliflozin (Qternmet XR)

(Video) Hyperkalemia - 11 drugs that increase your potassium levels

Selegiline (Eldepryl®)

Semaglutide- (Ozempic, Rybelsus)

Sitagliptin (Januvia®)

Sitagliptin + ertugliflozin (Steglujan)

Sitagliptin and Metformin HCL (Janumet®, Janumet XR)

Sodium ferric gluconate complex (Ferrlecit®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin cartridges®, Norditropin NordiFlex®, Nutropin, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)Sotalol (Betapace®, Betapace AF®, Sorine®)

Streptozocin (Zanosar®)

Sulfadiazine (Microsulfon®)

Tacrolimus P (Prograf®, Protopic®)

Tetracaine (Altacaine®, Tetcaine®, Pontocaine®)

Theophylline (Theo-24®, Theo-Dur®, TheoCap®)

Timolol (Timoptic®, Timoptic-XE®)

Tolazamide (Tolinase®)

Tolbutamide (Orinase®)

Topiramate (Topamax)

Tranylcypromine (Parnate®)Varenicline (Chantix®)

Verapamil (Calan®, Calan SR®, Isoptin SR®, Verelan®)

Drugs that can cause Hyper- or Hypoglycemia

Amphotericin B (Ambisome®, Amphocin®, Fungizone Intravenous® Amphotec®, Abelcet®)

Amphotericin B lipid formulations (Abelcet®, AmBisome®)

Avanafil (Stendra®)

Axitinib (Inlyta®)

Betaxolol Betoptic® eyedrops, (KERLONE® oral)

Bisoprolol + hydrochlorothiazide (Ziac®)

Choline salicylate (Numerous tradenames of aspirin formulations; check the label)

Choline salicylate + magnesium salicylate (CMT®, Tricosal®, Trilisate®)

Ciprofloxacin (Otiprio®)

Darunavir (Prezista®)

Diazoxide (Proglycem®)

Doxepin (Silenor®)

Elvitegravir + cobicistat + emtricitabine + tenofovir (Stribild®)

Emtricitabine + rilpivirine + tenofovir (Complera®)

Fentanyl (Abstral®, Lazanda®, Subsys®)

Fluoxetine (Prozac®, Sarafem®)

Hydrochlorothiazide + metoprolol (Lopressor HCT®)

Ivacaftor (Kalydeco®)

Lanreotide acetate (Somatuline®)

Lenalidomide (Revlimid®)

Lisinopril + Hydrochlorothiazide

Lithium (Eskalith®, Eskalith CR®, Lithobid®)

Magnesium salicylate (Bayer Select® Backache Pain Formula, Doans® Pills, Mobidin®, Nuprin® Backache Caplet)

Mecasermin (Increlex ®)

Mecasermin Rinfabate (Iplex ®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Nadolol (Corgard®)

Naproxen + esomeprazole (Vimovo®)

Drugs that can cause Hyper- or Hypoglycemia – Continued

Octreotide (Sandostatin®, Sandostatin LAR® Depot)

Omacetaxine (Synribo®)

Oxcarbazepine (Oxtellar XR®)

Oxycodone + acetaminophen (Xartemis®)

Pancrelipase (Ultresa®, Viokace®)

Paroxetine (Brisdelle®)

Pasireotide (Signifor®)

Pazopanib (Votrient ®)

Pentamidine (Nebupent®, Pentam 300®)

Phenytoin (Dilantin®, Dilantin-125®, Dilantin Infatabs®, Dilantin Kapseals®, Phenytek®)

Ponatinib

Rifampin (Rifadin®, Rimactane®)

Ritodrine (Yutopar®)

Rituximab (Rituxan®)

Salsalate (Argesic®-SA, Disalcid®, Mono-Gesic®, Salflex®, Salsitab®)

Sitagliptin + simvastatin (Juvisync®)

Sunitinib (Sutent®)

Somatropin (Genotropin®, Genotropin Miniquick®, Humatrope®, Norditropin cartridges®, Norditropin NordiFlex®, Nutropin®, Nutropin AQ®, Saizen®, Serostim®, Zorbtive®)

Sotalol (Betapace®, Betapace AF®, Sorine®)

Streptozocin (Zanosar®)

Sunitinib (Sutent®)

Pancrelipase (Pancreaze®)

Pasireotide (Signifor®)

Pegloticase (Krystexxa®)

Tacrolimus P (Prograf®, Protopic®)

Testosterone gel (Fortesta®)

Drugs that can cause Hyper- or Hypoglycemia – Continued

Testosterone (Aveed®, Natesto®, Vogelxo®)

Topiramate (Qudexy®)

Vandetanib (Vandetanib®)

Drugs that can MASK* Hypoglycemia

Atenolol (Tenormin®, Tenoretic® containing Atenolol & Chlorthalidone)

Carteolol (Cartrol® oral, Occupress® eyedrops)

Carvedilol (Coreg®, Coreg® Tiltabs®)

Clonidine (Duraclon®, Catapres®, Catapres-TTS-1®, Catapres-TTS-2®, Catapres-TTS-3®)

Metoprolol (Lopressor®, Lopressor® HCT, Toprol XL®)

Nadolol (Corgard®)

Nebivolol (Bystolic®)

Pindolol (Visken®)

Propranolol, Propranolol Hydrochloride, (Inderal®, Inderal LA®, Inderide®, Innopran® XL, Intensol®)

Timolol (Timoptic®, Timoptic-XE®)

_________________

* Recent research suggests that this may not occur.

__________________

Because of the continually changing nature of the U.S. prescription and OTC drug marketplace, this list may not reflect the full range of drugs that may impact blood glucose levels. The information contained in this document is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse, or pharmacist before taking any prescription or over-the-counter drugs (including any herbal medicines or supplements) or following any treatment or regimen.

References:

(Video) Anti-inflammatory drugs: "Aspirin", naproxen, ibuprofen, diclofenac, celecoxib and "Tylenol"

FAQs

What medications can affect blood sugar levels? ›

Antidepressants (Zyprexa, risperdal, Clozaril, Seroquel, Abilify, Geodon, lithium) Beta-2 stimulators (Proventil, Alupent, Serevent, Foradil, Brethine, Theo-Dur) Caffeine. Corticosteroids (Prednisone, Decadron, DepoMedrol)

What blood pressure meds cause high blood sugar? ›

Hydrochlorothiazide (HCTZ) and chlorthalidone are diuretics used to lower blood pressure but may increase your risk for high blood sugar and diabetes.

What vitamins and supplements raise blood sugar? ›

Vitamin B3 or Niacin, taken to reduce bad cholesterol, increases insulin resistance and raises blood sugar levels.

Can pain meds cause high glucose? ›

You also need to be careful about any pain relieving medication that you take, even if it's just on an occasional basis, because certain types of pain killers can lower or raise your blood sugar levels.

Can certain medications cause high blood sugar? ›

Many can, including steroids, anxiety and depression medications, statins, beta-blockers, some acne & asthma medications. Knowing which drugs affect blood glucose levels is essential in properly caring for your diabetes patients. Some medicines raise blood sugar in patients while others might lower their levels.

What vitamins should a diabetic not take? ›

Supplements That Diabetics Shouldn't Take
  • 1- Chromium: Even though studies have suggested that chromium may help keep blood sugar in check, it will not help you if you aren't deficient in this mineral. ...
  • 2- Vitamin E: ...
  • 3- Vitamin B: ...
  • 4- Magnesium:
3 Nov 2021

Can drinking a lot of water lower your blood sugar? ›

Drinking water regularly may rehydrate the blood, lower blood sugar levels, and reduce diabetes risk ( 20 , 21 ). Keep in mind that water and other zero-calorie drinks are best. Avoid sugar-sweetened options, as these can raise blood glucose, drive weight gain, and increase diabetes risk ( 22 , 23 ).

What is the new pill for diabetes? ›

Tirzepatide is the first drug in a new class of diabetes medications. It is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. GLP-1 and GIP are gut hormones called incretins, and the intestines release them when we eat.

What can I take instead of metformin? ›

Other alternatives to metformin
  • Avandia (rosiglitazone)
  • Nesina (alogliptin)
  • Tanzeum (albiglutide)
  • Jardiance (empagliflozin)
  • Invokana (canagliflozin)
  • Farxiga (dapagliflozin)
21 Mar 2022

What is the best medicine to lower A1C? ›

  • Alpha-glucosidase inhibitors. Acarbose (Precose) and miglitol (Glyset) are alpha-glucosidase inhibitors. ...
  • Biguanides. Metformin (Glucophage) is a biguanide. ...
  • Bile Acid Sequestrants (BASs) ...
  • Dopamine-2 Agonists. ...
  • DPP-4 Inhibitors. ...
  • Meglitinides. ...
  • SGLT2 Inhibitors. ...
  • Sulfonylureas.

Can vitamins raise blood sugar? ›

A number of over-the-counter (OTC) and prescription drugs — even some vitamins and supplements — can raise blood sugar.

Do statins raise your blood sugar? ›

It's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.

Does Tylenol raise your blood sugar? ›

Tylenol does not have an effect on blood glucose levels.

What is the miracle fruit for diabetes? ›

Miracle fruit, Synsepalum dulcificum, is commonly known to be an alternative sweetener. It makes sour food taste sweet by affecting the tongue's taste receptors. It also shows beneficial health effects, such as antioxidant, anti‐inflammatory, and antihyperglycemic activities.

Can low vitamin D cause high blood sugar? ›

Vitamin D deficiency has been linked to prediabetes, which is a blood glucose, or sugar, level that is too high but not high enough to be considered diabetes. It is unclear, however, if bringing low vitamin D blood levels to normal through supplementation will affect progression to diabetes.

What causes blood sugar to rise without eating? ›

Coffee—even without sweetener. Some people's blood sugar is extra-sensitive to caffeine. Losing sleep—even just one night of too little sleep can make your body use insulin less well. Skipping breakfast—going without that morning meal can increase blood sugar after both lunch and dinner.

Can you take oxycodone If you're diabetic? ›

Conclusion: CR oxycodone is effective and safe for the management of painful diabetic neuropathy and improves QOL.

What painkiller can I take with high blood pressure? ›

Acetaminophen (Tylenol) is often the pain reliever of choice for people with high blood pressure (hypertension) because most other options are types of nonsteroidal anti-inflammatory drugs like ibuprofen (Motrin, Advil) or naproxen (Naprosyn, Aleve), which can raise blood pressure.

Does tramadol affect blood sugar? ›

Does tramadol affect your blood sugar? Several studies show that tramadol can cause low blood sugar (hypoglycemia). This is most common in people with diabetes. Sometimes, hypoglycemia from tramadol can be severe and lead to hospitalization.

Does Tylenol raise your blood sugar? ›

Tylenol does not have an effect on blood glucose levels.

Does Claritin raise blood sugar? ›

Thankfully, antihistamines, including the popular allergy medicine Claritin, do not raise blood sugar. However, some products, such as Benadryl, may cause drowsiness, and interfere with your daily activities, including your diabetes care.

Can vitamins raise blood sugar? ›

A number of over-the-counter (OTC) and prescription drugs — even some vitamins and supplements — can raise blood sugar.

Do decongestants raise blood glucose? ›

Over-the-counter decongestants come in nasal spray, nose drop, pill and liquid form. They can help unblock a stuffy nose. But they may also raise your blood glucose and blood pressure levels. Consult with your doctor before using a decongestant.

What can cause a false high blood sugar reading? ›

However, various factors such as application errors, extreme environmental conditions, extreme hematocrit values, or medication interferences may potentially falsify blood glucose readings. Incorrect blood glucose readings may lead to treatment errors, for example, incorrect insulin dosing.

What is the new pill for diabetes? ›

Tirzepatide is the first drug in a new class of diabetes medications. It is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. GLP-1 and GIP are gut hormones called incretins, and the intestines release them when we eat.

Does caffeine raise blood sugar? ›

For most young, healthy adults, caffeine doesn't appear to noticeably affect blood sugar (glucose) levels, and having up to 400 milligrams a day appears to be safe.

Does Benadryl lower blood sugar? ›

Antihistamines—they tend to not affect blood sugar; however, antihistamines do tend to make you drowsy. Therefore, it is important to understand that long periods of drowsiness can also be associated with hypoglycemia and hyperglycemia. Drowsiness may make you less able to accurately monitor blood sugar.

What is the best medicine to lower a1c? ›

  • Alpha-glucosidase inhibitors. Acarbose (Precose) and miglitol (Glyset) are alpha-glucosidase inhibitors. ...
  • Biguanides. Metformin (Glucophage) is a biguanide. ...
  • Bile Acid Sequestrants (BASs) ...
  • Dopamine-2 Agonists. ...
  • DPP-4 Inhibitors. ...
  • Meglitinides. ...
  • SGLT2 Inhibitors. ...
  • Sulfonylureas.

Does omeprazole raise blood sugar? ›

Omeprazole therapy significantly improved blood glucose levels, as evidenced by the improvement in HbA1c levels. These findings are consistent with the findings of prior international studies, which used various combinations of anti-glycaemic agents in conjunction with PPIs and assessed the FBS and HbA1c levels.

Can low vitamin D cause high blood sugar? ›

Vitamin D deficiency has been linked to prediabetes, which is a blood glucose, or sugar, level that is too high but not high enough to be considered diabetes. It is unclear, however, if bringing low vitamin D blood levels to normal through supplementation will affect progression to diabetes.

Does vitamin D Help glucose levels? ›

Vitamin D supplementation may help lower average blood sugar levels in people with type 2 diabetes; and is especially effective in people who also have a vitamin D deficiency, and are non-obese and deficient. Supplementation for more than 12 weeks at ≥ 1000 IU/day may be most beneficial.

What is the best vitamin for diabetics? ›

What are the best vitamins for people with diabetes?
  • Thiamin (b1) Those with type 1 or type 2 diabetes are more likely to have lower blood levels of thiamin and usually suffer a higher risk of thiamin deficiency than people who don't have diabetes. ...
  • Vitamin B12. ...
  • Vitamin D. ...
  • Magnesium. ...
  • Vitamin E. ...
  • Vitamin C.
8 Apr 2021

Does Flonase nasal spray raise blood sugar? ›

Conclusion: Intranasal corticosteroids seem to have no adverse effects on HbA1c and serum glucose levels in diabetic patients.

Does sinus medicine raise blood sugar? ›

Make sure you tell your doctor if you have any other medical problems, especially: Type 2 diabetes mellitus—Use of pseudoephedrine may cause an increase in blood glucose levels.

Can nasal spray cause high blood sugar? ›

Nose spray—some have chemicals that trigger your liver to make more blood sugar.

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