2022 Lipidomics Conference GRC (2022)

Conference Description

The field of lipidomics centers on the comprehensive study of lipid or fat molecules in cells, tissues, and biofluids. This diagnostic approach studies quantifiable information about the content, profile and interaction of lipids, which are of the most common biological molecules in humans. The lipidome of human plasma or eukaryotic cells contains thousands of lipid entities that structurally and chemically play fundamental roles in cellular membrane regulation, energy storage, or become precursors to bioactive metabolites. Alterations in the lipid content therefore becomes indicative of certain biological, medical, disease and health states. Driven by high expectation in its ability to afford new opportunities for studying lipids in health and disease, and in many other fields of research, lipidomics has meticulously emerged over the past decade. In fact, initial evidence of its power is emerging that draws major attention to the field, resulting in a wave of interest in adopting lipidomics capabilities across research communities. The full release of lipidomics now waits on the standardization of the field.

We anticipate standardization will release the current handbrakes and dramatically boost the lipidomics evolvement worldwide, targeting a transition into the medical community and becoming apart of tomorrow's clinical chemistry. We highly foresee that lipidomic analysis tests alone, or in concert with other present chemical analyses, will provide higher defined metabolic signatures that more accurately describes the molecular profiles underlying specific diseases and their progression, and greatly aid in their diagnosis and prevention. Concomitantly, a myriad of sophisticated lipidomic workflows covering analytical and bioinformatical strategies have recently been developed to delineate lipidomes of diverse origins in great detail and quantitatively.

In this Gordon Conference series, we will highlight recent developments in standardization, omics integration, and state-of-the-art technologies and their impact on applications to study human health and disease. The time is critical to set the future cornerstones in how to powerfully, adequately, and transparently define the lipidomics rules of new and existing platforms in basic research, and most importantly, in a regulatory environment. Overall, the future of lipidomics in the clinical and biological realms will be discussed at this conference, aligning with other ongoing consortia, with an anticipated active involvement of researchers across all important arenas (academic, industry, government) and different stages of their career (established and young scientists).

Sunday
2:00 pm - 9:00 pm

Arrival and Check-in

6:00 pm - 7:00 pm

Dinner

7:30 pm - 7:40 pm

Introductory Comments by GRC Site Staff / Welcome from the GRC Chair

7:40 pm - 9:30 pm

Lipidomics in Decoding Biology

Discussion Leader: William Griffith (Swansea University Medical School, United Kingdom)

7:40 pm - 7:45 pm

Introduction by Discussion Leader

7:45 pm - 8:15 pm

Vytas Bankaitis (texas a&m university, United States)

"Lipid Exchange Proteins and Regulation of Phosphoinositide Signaling"

8:15 pm - 8:25 pm

Discussion

8:25 pm - 8:55 pm

William Holland (University of Utah, United States)

"Familial Hyperceramidemia in Diabetes and End-Stage Renal Disease"

8:55 pm - 9:00 pm

Discussion

9:00 pm - 9:10 pm

Federica Ferrentino (King's college london, United Kingdom)

"Lipidomic Changes Impact the Morphology of the Endoplasmic Reticulum"

9:10 pm - 9:15 pm

Discussion

9:15 pm - 9:25 pm

Nils Hoffmann (IBG-5, Forschungszentrum Jülich GmbH, Germany)

"LipidCompass - A Reference Database for Quantitative Lipidomics"

9:25 pm - 9:30 pm

Discussion

Monday
7:30 am - 8:30 am

Breakfast

9:00 am - 12:30 pm

Lipidomics in Human Health and Disease

Discussion Leader: Edward Dennis (University of California, San Diego, United States)

9:00 am - 9:05 am

Introduction by Discussion Leader

9:05 am - 9:35 am

Michal Holcapek (University of Pardubice, Czech Republic)

"Early Detection of Pancreatic Cancer Based on Blood Lipidome: Translation from Academic Laboratory into Clinical Screening"

9:35 am - 9:45 am

Discussion

9:45 am - 10:15 am

Michael Kiebish (Berg, LLC, United States)

"Interrogating Human Biology to Discover Novel Signaling Lipid Drivers of Metabolism as Well as Disease Intervention"

10:15 am - 10:25 am

Discussion

10:25 am - 10:50 am

Coffee Break

10:50 am - 11:20 am

Jung Suh (Denali Therapeutics, United States)

"Tauopathy Stroking the Flames of ApoE4 Toxicity"

11:20 am - 11:30 am

Discussion

11:30 am - 11:40 am

Mélanie Plourde (Université de Sherbrooke, Canada)

"Lipidomics of the Lateral Ventricle Choroid Plexus during Aging"

(Video) Question Period – September 28, 2022

11:40 am - 11:45 am

Discussion

11:45 am - 11:55 am

Yuqin Wang (Swansea University, United Kingdom)

"Sterols as Lipid Biomarkers for Huntington’s Disease"

11:55 am - 12:00 pm

Discussion

12:00 pm - 12:10 pm

Shreyoshi Chakraborti (Stony Brook University, United States)

"Understanding the Role of Lipids in the Mechanism of Action of melH, a Key Regulator of Oxidative Stress in Mycobacterium Tuberculosis"

12:10 pm - 12:15 pm

Discussion

12:15 pm - 12:25 pm

Arieh Moussaieff (The Hebrew University, Israel)

"Lipid Desaturation Regulates the Balance between Self-renewal and Differentiation in Blastocyst-derived Stem Cells"

12:25 pm - 12:30 pm

Discussion

12:30 pm - 1:30 pm

Lunch

1:30 pm - 4:00 pm

Free Time

3:00 pm - 4:00 pm

The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.

Organizer: Erin Baker (University of North Carolina, United States)

4:00 pm - 6:00 pm

Poster Session

6:00 pm - 7:00 pm

Dinner

7:30 pm - 9:30 pm

Harmonization and Standardization in Lipidomics

Discussion Leader: Valerie O'Donnell (Cardiff University, United Kingdom)

7:30 pm - 8:00 pm

Markus Wenk (National University of Singapore, Singapore)

"Variabilities and Reference Ranges of Human Blood Plasma Lipids"

8:00 pm - 8:10 pm

Discussion

8:10 pm - 8:20 pm

Laura Goracci (University of Perugia, Italy)

"From Lipostar to Lipostar 2: New Tools and Workflows for LC-MS Based Untargeted Lipidomics"

8:20 pm - 8:25 pm

Discussion

8:25 pm - 8:55 pm

Jeffrey McDonald (UT Southwestern Medical Center, United States)

"Defining the Lipidomics Minimal Reporting Checklist to Establish Harmony, Quality, and Transparency"

8:55 pm - 9:00 pm

Discussion

9:00 pm - 9:20 pm

Gerhard Liebisch (University Hospital Regensburg, Germany)

"Lipidomics Minimal Reporting Checklist"

9:20 pm - 9:30 pm

Discussion

Tuesday
7:30 am - 8:30 am

Breakfast

9:00 am - 12:30 pm

Novel Lipidomic Mass Spectrometry Strategies

Discussion Leader: System.String[]

9:00 am - 9:05 am

Introduction by Discussion Leader

9:05 am - 9:35 am

André Nadler (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)

"Imaging Lipid Flux on Subcellular Scales"

9:35 am - 9:45 am

Discussion

9:45 am - 10:15 am

Boone Prentice (University of Florida, United States)

"Identification of Isobaric and Isomeric Lipids in Imaging Mass Spectrometry Using Gas-Phase Ion/Ion Reactions"

(Video) Question Period – September 29, 2022

10:15 am - 10:25 am

Discussion

10:25 am - 10:50 am

Group Photo / Coffee Break

10:50 am - 11:20 am

Christoph Thiele (University of Bonn, Germany)

"Multiparallel Alkyne Lipid Tracing to Study the Dynamics of Triglyceride Storage"

11:20 am - 11:30 am

Discussion

11:30 am - 11:40 am

Kyle Saunders (University of Surrey, United Kingdom)

"Optimization of Single Cell Lipidomics Using Nanocapillary Sampling and Mass Spectrometry"

11:40 am - 11:45 am

Discussion

11:45 am - 11:55 am

Xin Ma (Georgia Institute of Technology, United States)

"Spatially Resolved Lipidomic Profiling of Ovarian Cancer Using Ultrahigh Resolution Mass Spectrometry Imaging"

11:55 am - 12:00 pm

Discussion

12:00 pm - 12:10 pm

Laura Bailey (University of Florida, United States)

"Reinvention and Validation of the Sulfo-Phospho-Vanillin Assay for Sample Normalization in Quantitative Lipidomic LC-MS/MS"

12:10 pm - 12:15 pm

Discussion

12:15 pm - 12:25 pm

Ingela Lanekoff (Uppsala University, Sweden)

"Isomeric Differentiation of Silver Cationized Lipids using Direct Infusion and MSn"

12:25 pm - 12:30 pm

Discussion

12:30 pm - 1:30 pm

Lunch

1:30 pm - 4:00 pm

Free Time

4:00 pm - 6:00 pm

Poster Session

6:00 pm - 7:00 pm

Dinner

7:30 pm - 9:30 pm

Clinical and Translational Lipidomics

Discussion Leader: Dawn Dufield (KCAS, United States)

7:30 pm - 7:35 pm

Introduction by Discussion Leader

7:35 pm - 8:05 pm

Daisuke Saigusa (Teikyo University, Japan)

"Lipidomic Profiling in the Large-Scale Cohort for Biomarker Discovery and the Importance of Separation Science"

8:05 pm - 8:15 pm

Discussion

8:15 pm - 8:45 pm

Peter Åkerblad (Albireo Pharma, Sweden)

"A3907 a Clinical Systemically Available ASBT Inhibitor – Lipidomic Fingerprinting of NASH Models Translating to Effects in Humans"

8:45 pm - 8:55 pm

Discussion

9:35 pm - 9:45 pm

Cecile Gladine (INRAE, France)

"The Plasma Oxylipin Signature Provides a Fine Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria"

9:45 pm - 9:50 pm

Discussion

9:50 pm - 10:00 pm

Valerie O'Donnell (Cardiff University, United Kingdom)

"How to Follow Accepted International Practice for Analysis of Small Molecules when Analyzing Oxylipins"

10:00 pm - 10:05 pm

Discussion

10:05 pm - 10:10 pm

General Discussion

Wednesday
7:30 am - 8:30 am

Breakfast

9:00 am - 12:30 pm

Lipidomics Data Dimensions and Biological Interpretation

Discussion Leader: John McLean (Vanderbilt Universtiy, United States)

(Video) The News - September 28, 2022

9:00 am - 9:05 am

Introduction by Discussion Leader

9:05 am - 9:35 am

Erin Baker (University of North Carolina, United States)

"Fingerprinting How Lipids are Affected by Exposure with LC-IMS-CID-MS"

9:35 am - 9:45 am

Discussion

9:45 am - 10:15 am

Steffany Bennett (University of Ottawa, Canada)

"Aberrant Sphingolipid and Phospholipid Metabolism are Defining Dementia Pathologies that Discriminate Cognitively Normal Aging from Alzheimer’s Disease and Dementia with Lewy Bodies"

10:15 am - 10:25 am

Discussion

10:25 am - 10:55 am

Coffee Break

10:55 am - 11:25 am

Andrej Shevchenko (MPI of Molecular Cell Biology and Genetics, Germany)

"Tissue Lipidomics by Ultra-High Resolution Mass Spectrometry"

11:25 am - 11:35 am

Discussion

11:35 am - 12:05 pm

Xue Li Guan (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore)

"Microbial Lipids - A Greasy Business"

12:05 pm - 12:15 pm

Discussion

12:15 pm - 12:25 pm

Kelly Hines (University of Georgia, United States)

"RPLC-IM-MS to Monitor Host-Derived Lipid Utilization by Staphylococcus Aureus"

12:25 pm - 12:30 pm

Discussion

12:30 pm - 1:30 pm

Lunch

1:30 pm - 4:00 pm

Free Time

4:00 pm - 5:30 pm

Poster Session

5:30 pm - 7:30 pm

Resolving Lipid Metabolic Networks

Discussion Leader: Gavin Reid (University of Melbourne, Australia)

5:30 pm - 5:35 pm

Introduction by Discussion Leader

5:35 pm - 6:05 pm

Charles Serhan (Harvard University, United States)

"Human Neutrophils and Macrophages Biosynthesize Cell Type Specific Resolvins from the 4S,5S-epoxy-Resolvin Intermediate that Regulate Inflammation-Resolution, Tissue Regeneration, and Granuloma Formation"

6:05 pm - 6:15 pm

Discussion

6:15 pm - 6:45 pm

Nathan Hatcher (Merck & Co., Inc., United States)

"Unraveling Complex Lipid Biology using Stable Isotopically Labeled Tracer-Based Assays"

6:45 pm - 6:55 pm

Discussion

6:55 pm - 7:25 pm

Jace Jones (University of Maryland, School of Pharmacy, United States)

"Diacyl and Ether Glycerophosphoethanolamine Oxidation Susceptibility Following Lipid Peroxidation: Application to Traumatic Brain Injury"

7:25 pm - 7:30 pm

Discussion

8:00 pm - 9:00 pm

Dinner

Thursday
7:30 am - 8:30 am

Breakfast

8:30 am - 9:00 am

Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)

9:00 am - 12:30 pm

Role of the Environment on the Lipidome

Discussion Leader: Nancy Denslow (University of Florida, United States)

9:00 am - 9:05 am

Introduction by Discussion Leader

9:05 am - 9:35 am

Laila Abdullah (Roskamp Institute, United States)

"APOE4 Mediated Disruption of the L-Carnitine System Contributes to Bioenergetic Deficits in Neurological Disorders"

(Video) Oliver Fiehn- April 12th 2022

9:35 am - 9:45 am

Discussion

9:45 am - 10:15 am

Jeremy Koelmel (Julius Sun, United States)

"Dynamic Environment, Dynamic Lipidome: Probing System Wide Lipid Changes Using Novel Software"

10:15 am - 10:25 am

Discussion

10:25 am - 10:50 am

Coffee Break

10:50 am - 11:20 am

Kuniyuki Kano (The University of Tokyo, Japan)

"Visualization of Phospholipid Metabolism Based on MS Imaging Technology"

11:20 am - 11:30 am

Discussion

11:30 am - 11:40 am

Michiel Vandenbosch (Maastricht University, The Netherlands)

"Quantitative Mass Spectrometry Imaging to Study Lipid Metabolism in Parkinson’s Disease Model"

11:40 am - 11:45 am

Discussion

11:45 am - 11:55 am

Kaylie Kirkwood (North Carolina State University, United States)

"Elucidating Lipid Dysregulation in Mice Exposed to Various Perfluoroalkyl Substances (PFAS) with Multidimensional Measurements"

11:55 am - 12:00 pm

Discussion

12:00 pm - 12:10 pm

Ken Stark (University of Waterloo, Canada)

"Lipidomic Biomarkers of Dietary Omega-3 Polyunsaturated Fatty Acids"

12:10 pm - 12:15 pm

Discussion

12:15 pm - 12:25 pm

Dolma Michellod (MPI for marine microbiology, Germany)

"Phytosterol Synthesis within the Animal Kingdom"

12:25 pm - 12:30 pm

Discussion

12:30 pm - 1:30 pm

Lunch

1:30 pm - 4:00 pm

Free Time

4:00 pm - 6:00 pm

Poster Session

6:00 pm - 7:00 pm

Dinner

7:30 pm - 9:30 pm

Integration of Lipidomics with Genomics, Proteomics and Metabolomics

Discussion Leader: Vladimir Capka (Senda Biosciences, United States)

7:30 pm - 7:35 pm

Introduction by Discussion Leader

7:35 pm - 8:05 pm

Bjoern Titz (Philip Morris International R&D, Switzerland)

"Lipidomics in Multi-Omics Toxicology and Disease Studies"

8:05 pm - 8:15 pm

Discussion

8:15 pm - 8:45 pm

Peter Meikle (Baker Heart and Diabetes Institute, Australia)

"Comprehensive Genetic Analysis of the Human Lipidome Identifies Novel Loci Controlling Lipid Homeostasis with Links to Coronary Artery Disease"

8:45 pm - 8:55 pm

Discussion

8:55 pm - 9:05 pm

Miroslava Cuperlovic-Culf (National Research Council of Canada, Canada)

"Gaussian Process Regression Selection of Principal Distance Correlation Partners for Determination of Lipidomics and Metabolomics Network Changes in Acute COVID-19 Infection"

9:05 pm - 9:10 pm

Discussion

9:10 pm - 9:20 pm

Patrycja Puchalska (UMN, United States)

"Artifactual FA Dimers Mimic FAHFA Signals in Untargeted Metabolomics Pipelines"

9:20 pm - 9:25 pm

Discussion

9:25 pm - 9:30 pm

Closing Remarks

(Video) JET POWER 2022 - JETS & PROPS - EVERYTHING NEW!!!!

Friday
7:30 am - 8:30 am

Breakfast

9:00 am

Departure

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